That will be a lot of driving.
I am not so familiar with the White Mountains or Adirondack Park. I know that you can drive from Boston to Niagara Falls in about 8 hours if you take the southern route and stay on the interstate highways. If you go through the mountains, it will take a lot longer. These are not high mountains with snow capped peaks. They are lower mountains covered with forests and some rocky peaks. The roads through the mountains can be very scenic, but they can also cause very slow driving especially when you get stuck behind some big slow logging trucks. Fortunately, October is usually a very pretty time. The leaves on the trees should be changing from green to many bright colors. These hardwood forests display some really beautiful colors during a few weeks in early October.